Drug Insight: abatacept for the treatment of rheumatoid arthritis

被引：0
作者：
Eric M Ruderman
Richard M Pope
机构：
[1] Division of Rheumatology at the Northwestern University Feinberg School of Medicine,
[2] Division of Rheumatology at the Northwestern University Feinberg School of Medicine,undefined
来源：
Nature Clinical Practice Rheumatology | 2006年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Targeting the co-stimulatory signals that accompany antigen-derived signals involved in the activation of T cells represents a possible therapeutic approach for patients with rheumatoid arthritis. This Review focuses on abatacept, a fusion protein that interrupts the co-stimulatory signal mediated through the CD28–CD80/CD86 pathway, and discusses its proposed mechanism of action and outlines data from clinical trials in rheumatoid arthritis.
引用
收藏
页码：654 / 660
页数：6
相关论文
共 25 条
[1]  
Firestein GS(2003)Evolving concepts of rheumatoid arthritis Nature 423 356-361
[2]  
Keystone EC(2003)Abandoned therapies and unpublished trials in rheumatoid arthritis Curr Opin Rheumatol 15 253-258
[3]  
Moreland LW(2002)Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion Arthritis Rheum 46 1470-1479
[4]  
Kremer JM(2003)Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig N Engl J Med 349 1907-1915
[5]  
Kremer JM(2005)Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial Arthritis Rheum 52 2263-2271
[6]  
Genovese MC(2005)Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition N Engl J Med 353 1114-1123
[7]  
Kremer JM(2006)Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis Ann Intern Med 144 865-876
[8]  
Bluestone JA(2006)CTLA4Ig: bridging the basic immunology with clinical application Immunity 24 233-238
[9]  
Salomon B(2000)B7/CD28 costimulation is essential for the homeostasis of the CD4 Immunity 12 431-440
[10]  
Linsley PS(1991)CD25 J Exp Med 174 561-569
123