Evidence for the embryonic origin of partial chromosome 7 deletion in monozygotic twins with juvenile chronic myelogenous leukemia

被引：0

作者：

V Najfeld

A Vlachos

R Parker

W Burnett

A Scalise

S Fruchtman

机构：

[1] Tumor Cytogenetics Laboratory and The Bone Marrow Transplantation Service,Division of Hematology, Department of Medicine

[2] Mount Sinai School of Medicine,Division of Hematology/Oncology, Department of Pediatrics

[3] Mount Sinai School of Medicine,Department of Pediatrics

[4] Hematology-Oncology,undefined

[5] Children’s Medical Center,undefined

[6] State University of New York at Stony Brook,undefined

来源：

Leukemia | 1997年 / 11卷

关键词：

JCML; monosomy 7; del(7); interphase; metaphase FISH;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

During donor evaluation for allogeneic bone marrow transplantation (BMT) of a 28-month-old child with juvenile chronic myelogeneous leukemia (JCML) with 46,XY,−7,+mar karyotype, the potential donor twin brother was found to be thrombocytopenic. Subsequent genotype analysis determined monozygosity with 98% probability. Bone marrow analysis of the twin brother revealed the same 46,XY,−7,+mar karyotype and a diagnosis of JCML was made. Metaphase FISH studies documented that mar chromosome in both twins contains the pericentromeric region of chromosome 7 and thus both twins had a partial monosomy of chromosome 7. A possible embryonic origin of del(7) is proposed.

引用

页码：306 / 310

页数：4