Serum and urine levels of tamoxifen and its metabolites in patients with advanced breast cancer after a loading dose and at steady-state levels

被引：0

作者：

Dick de Vos

Peter H. T. J. Slee

Ray J. Briggs

Derek Stevenson

机构：

[1] Medical Department Pharmachemie BV,

[2] P.O.Box 552,undefined

[3] 2003 RN Haarlem,undefined

[4] The Netherlands Tel.: +31-23-5147 147,undefined

[5] Fax: +31-23-5147 774,undefined

[6] St. Antonius Hospital,undefined

[7] 3435 CM Nieuwegein,undefined

[8] The Netherlands,undefined

[9] Robens Analytical Centre,undefined

[10] School of Biological Science,undefined

[11] University of Surrey,undefined

[12] Guildford,undefined

[13] Surrey GU2 5XH,undefined

[14] UK,undefined

来源：

Cancer Chemotherapy and Pharmacology | 1998年 / 42卷

关键词：

Key words Tamoxifen; Serum levels; Urinary excretion; Loading dose; Steady state;

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学科分类号：

摘要：

Purpose: To compare serum and urine levels of tamoxifen and metabolites after a loading dose and at the steady state. Methods: A loading dose of 160 mg of tamoxifen was given to 14 patients with advanced breast cancer. Thereafter a regular daily dose of 30 mg of tamoxifen was given. Serum and urine levels of tamoxifen and metabolites were measured by high-performance liquid chromatography and compared with levels determined in 31 patients with advanced breast cancer at the steady state at a daily dose of 30 mg of tamoxifen. Results: Serum and urine levels (24-h values) of tamoxifen and metabolites were lower (P<0.05) after a loading dose than at the steady state. The difference was most pronounced for the metabolites, whereas the tamoxifen loading-dose level was near the steady state. Conclusion: Tamoxifen steady state can be reached in 1–2 days by the administration of a loading dose of 160 mg of tamoxifen for 2 days. Tamoxifen metabolite steady-state levels are reached regularly after 4 or more weeks during application of a loading dose. Very little tamoxifen or metabolites are excreted into the urine.

引用

页码：512 / 514

页数：2