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Guangdong Acad Med Sci, Dept Cardiol, Guangdong Cardiovasc Inst,Guangdong Gen Hosp, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou 510080, Guangdong, Peoples R China Guangdong Acad Med Sci, Dept Cardiol, Guangdong Cardiovasc Inst,Guangdong Gen Hosp, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou 510080, Guangdong, Peoples R China