Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases

被引：0
作者：
X Yu
S Wieczorek
A Franke
H Yin
M Pierer
C Sina
T H Karlsen
K M Boberg
A Bergquist
M Kunz
T Witte
W L Gross
J T Epplen
M E Alarcón-Riquelme
S Schreiber
S M Ibrahim
机构：
[1] Section of Immunogenetics,Department of Human Genetics
[2] University of Rostock,Department of Genetics and Pathology
[3] Ruhr University,Medical Department IV
[4] IGSN,Department of General Internal Medicine
[5] Institute of Clinical Molecular Biology,Medical Department
[6] Christian-Albrechts-University,Department of Gastroenterology and Hepatology
[7] Uppsala University,Department of Immunology and Rheumatology
[8] University of Leipzig,Department of Rheumatology
[9] University Hospital Schleswig-Holstein,undefined
[10] Christian-Albrechts-University,undefined
[11] Rikshospitalet University Hospital,undefined
[12] Karolinska University Hospital,undefined
[13] Dermatology Clinic,undefined
[14] University of Rostock,undefined
[15] Medical School Hannover,undefined
[16] University Hospital of Schleswig-Holstein,undefined
[17] Campus Luebeck,undefined
来源：
Genes & Immunity | 2009年 / 10卷
关键词：
mitochondria; chronic inflammatory diseases; uncoupling protein 2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We reported earlier that two mitochondrial gene polymorphisms, UCP2 –866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis (MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg–Strauss syndrome (CSS), Crohn's disease (CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. Compared with individual control panels, the UCP2 –866 G/A polymorphism was associated with RA and SLE, and the mtDNA nt13708 G/A polymorphism with RA. Compared with combined controls, the UCP2 –866 G/A polymorphism was associated with SLE, WG, CD and UC. When all eight disease panels and the original MS panel were combined in a meta-analysis, the UCP2 was associated with chronic inflammatory diseases in terms of either alleles (odds ratio (OR)=0.91, 95% confidence interval (95% CI): 0.86–0.96), P=0.0003) or genotypes (OR=0.88, (95% CI: 0.82–0.95), P=0.0008), with the –866A allele associated with a decreased risk to diseases. As the −866A allele increases gene expression, our findings suggest a protective role of the UCP2 protein in chronic inflammatory diseases.
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页码：601 / 605
页数：4
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