Osteoclast-activating system in cosmonauts after long-term international space station missions

被引：0

作者：

Morukov I.B. ^{[1
]}

Rykova M.P. ^{[1
]}

Antropova E.N. ^{[1
]}

Berendeeva T.A. ^{[1
]}

Ponomarev S.A. ^{[1
]}

Morukov B.V. ^{[1
]}

机构：

[1] Institute of Biomedical Problems, Russian Academy of Sciences, Moscow

来源：

Human Physiology | 2016年 / 42卷 / 7期

关键词：

OPG; RANKL; space flights;

D O I：

10.1134/S0362119716070124

中图分类号：

学科分类号：

摘要：

The results of studying the system of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) in 22 Russian cosmonauts after long-term (124–199 days) International Space Station missions are presented. It was found that early readaptation period is associated with changes in the serum concentrations of OPG and RANKL and the production rate of OPG and RANKL in phytohemagglutinin (PHA)-stimulated and non-stimulated mononuclear cells of peripheral blood in vitro. The extent of these changes varied in different subjects. Our data suggest that the OPG/RANKL cytokine system takes part in the processes of bone remodeling in cosmonauts after long-term missions. © 2016, Pleiades Publishing, Inc.

引用

页码：719 / 723

页数：4

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