Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations

被引：0
作者：
Evangeline C. Kurtz-Nelson
See Wan Tham
Kaitlyn Ahlers
Daniel Cho
Arianne S. Wallace
Evan E. Eichler
Raphael A. Bernier
Rachel K. Earl
机构：
[1] University of Washington,Department of Psychiatry and Behavioral Sciences
[2] University of Washington,Department of Anesthesiology and Pain Medicine
[3] Seattle Children’s Research Institute,Department of Genome Sciences
[4] Seattle Children’s Autism Center,undefined
[5] University of Washington,undefined
[6] Howard Hughes Medical Institute,undefined
来源：
Journal of Autism and Developmental Disorders | 2021年 / 51卷
关键词：
Autism spectrum disorder; Intellectual disability; Rare genetic disorders; Self-injurious behavior; Abdominal pain;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population.
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页码：3365 / 3373
页数：8
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