T-loops and the origin of telomeres

被引：0
作者：
Titia de Lange
机构：
[1] the Laboratory for Cell Biology and Genetics,
[2] Box 159,undefined
[3] The Rockefeller University,undefined
来源：
Nature Reviews Molecular Cell Biology | 2004年 / 5卷
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摘要：
Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based system. Telomerase maintains specific repetitive sequences, which protect chromosome ends with the help of telomere-binding proteins. How did this elaborate system evolve? Here, I propose that telomere function was originally mediated by t-loops, which could have been generated by prokaryotic DNA-replication factors. These early telomeres would have required only the presence of a few repeats at chromosome ends. Telomerase could have been a later innovation with specific advantages for telomere function and regulation.
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页码：323 / 329
页数：6
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