Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system

[1] Almeria C(2019)Hypoxia conditioned mesenchymal stem cell-derived extracellular vesicles induce increased vascular tube formation in vitro Front Bioeng Biotechnol 7 1-12

[2] Weiss R(2022)Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions Cell Biosci 12 1-15

[3] Roy M(2013)Role of stem-cell-derived microvesicles in the paracrine action of stem cells Biochem Soc Trans 41 283-287

[4] Tripisciano C(2019)A novel 3D in vitro platform for pre-clinical investigations in drug testing, gene therapy, and immuno-oncology Sci Rep 9 1-12

[5] Kasper C(2020)Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury Stem Cell Res Ther 11 1-13

[6] Weber V(2014)Frequent occurrence of non-malignant genetic alterations in clinical grade mesenchymal stromal cells expanded for cell therapy protocols Haematologica 99 584-594

[7] Egger D(2021)A scalable coaxial bioprinting technology for mesenchymal stem cell microfiber fabrication and high extracellular vesicle yield Biofabrication 14 553444-2794

[8] Almeria C(2013)Short-term spheroid formation enhances the regenerative capacity of adipose-derived stem cells by promoting stemness, angiogenesis, and chemotaxis Stem Cells Transl Med 2 51-23

[9] Kreß S(2020)Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-/xeno-free conditions in a microcarrier-based bioreactor culture system Front Cell Dev Biol 8 2771-1759

[10] Weber V(2017)Development and characterization of a parallelizable perfusion bioreactor for 3D cell culture Bioengineering 4 19671-2019

[1] Almeria C(2019)Hypoxia conditioned mesenchymal stem cell-derived extracellular vesicles induce increased vascular tube formation in vitro Front Bioeng Biotechnol 7 1-12

[2] Weiss R(2022)Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions Cell Biosci 12 1-15

[3] Roy M(2013)Role of stem-cell-derived microvesicles in the paracrine action of stem cells Biochem Soc Trans 41 283-287

[4] Tripisciano C(2019)A novel 3D in vitro platform for pre-clinical investigations in drug testing, gene therapy, and immuno-oncology Sci Rep 9 1-12

[5] Kasper C(2020)Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury Stem Cell Res Ther 11 1-13

[6] Weber V(2014)Frequent occurrence of non-malignant genetic alterations in clinical grade mesenchymal stromal cells expanded for cell therapy protocols Haematologica 99 584-594

[7] Egger D(2021)A scalable coaxial bioprinting technology for mesenchymal stem cell microfiber fabrication and high extracellular vesicle yield Biofabrication 14 553444-2794

[8] Almeria C(2013)Short-term spheroid formation enhances the regenerative capacity of adipose-derived stem cells by promoting stemness, angiogenesis, and chemotaxis Stem Cells Transl Med 2 51-23

[9] Kreß S(2020)Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-/xeno-free conditions in a microcarrier-based bioreactor culture system Front Cell Dev Biol 8 2771-1759

[10] Weber V(2017)Development and characterization of a parallelizable perfusion bioreactor for 3D cell culture Bioengineering 4 19671-2019