Synthesis and structure of 2-methyl-6-oxo-7,8-dihydrospiro (benzo[h]-triazolo[3,4-b]quinazoline-7,1′-cyclopentane)

被引：0

作者：

Markosyan A.I. ^{[1
]}

Kuroyan R.A. ^{[1
]}

Dilanyan S.V. ^{[1
]}

Aleksanyan M.S. ^{[2
]}

Karapetyan A.A. ^{[2
]}

Struchkov Yu.T. ^{[2
]}

机构：

[1] A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia

[2] Center for the Study of Molecular Structure, National Academy of Science of the Republic of Armenia

来源：

Chemistry of Heterocyclic Compounds | 2000年 / 36卷 / 05期

关键词：

Benzo[h]quinazolines; Condensation; Cyclization; Methylation; Triazole;

D O I：

10.1007/BF02290848

中图分类号：

学科分类号：

摘要：

The reaction of 4-amino-3-ethoxvcarbonyl-1,2-dihydrospiro (naphthalene-2,1′-cyclopentane) with benzoyl isothiocyanate led to the corresponding 4-(N′-benzoylthioureido) derivative, the cyclization of which gave 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro (benzo[h]quinazoline-5,1′-cyclopentane). Condensation of the latter with hydrazine hydrate gave 2-hydrazino-3,4,5,6-tetrahydrospiro (benzo[h]quinazoline-5,1′-cyclopentane), which formed 6-oxo-1H-7,8-dihydrospiro (benzo[h]triazolo[3,4-b]quinazoline-7,1′-cyclopentane) in reaction, with orthoformic ester. Methylation of the product with methyl iodide led to its 2-methyl derivative.

引用

页码：574 / 578

页数：4