2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γnes: structure and activity relationship in cytotoxic activity

被引：0
|
作者：
Yong Kim
Young-Jae You
Nguyen-Hai Nam
Byung-Zun Ahn
机构：
[1] Chungnam National University,College of Pharmacy
来源：
Archives of Pharmacal Research | 2002年 / 25卷
关键词：
Yatein analogues; Deoxypodophyllotoxin analogues; Cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ(TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.
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页码：240 / 249
页数：9
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