Longitudinal variation in O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

被引：0
|
作者：
N P Lees
K L Harrison
E Hill
C N Hall
G P Margison
A C Povey
机构：
[1] Cancer Research UK,Department of General Surgery
[2] Carcinogenesis Group,undefined
[3] Paterson Institute for Cancer Research,undefined
[4] Wythenshawe Hospital,undefined
[5] School of Epidemiology and Health Sciences,undefined
[6] University of Manchester,undefined
来源：
British Journal of Cancer | 2002年 / 87卷
关键词：
-alkylguanine DNA-alkyltransferase; MGMT; colon;
D O I：
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中图分类号：
学科分类号：
摘要：
In a systematic study of O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O6-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
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页码：168 / 170
页数：2
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