Endothelial progenitor cells for postnatal vasculogenesis

被引：87
作者：
Eguchi M. [1 ]
Masuda H. [1 ]
Asahara T. [1 ,2 ]
机构：
[1] Department of Regenerative Medicine Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Bohseidai
[2] Stem Cell Translational Research, Institute of Biomedical Research and Innovation, RIKEN Center for Developmental Biology, Kobe
来源：
Clinical and Experimental Nephrology | 2007年 / 11卷 / 1期
关键词：
Angiogenesis; Cardiovascular disease; Cell therapy; Endothelial progenitor cells (EPCs); Renal stem cell; Therapeutic neovascularization; Vasculogenesis;
D O I：
10.1007/s10157-006-0448-1
中图分类号：
学科分类号：
摘要：
Bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and are home to - as well as incorporate into - sites of neovascularization. On the basis of these aspects, EPCs have attractive potential therapeutic applications for cardiovascular ischemic diseases as a novel cell-based strategy, mainly via a vasculogenesis mechanism. This review provides an update of the biology of EPCs, as well as highlighting the potential use of these cells for therapeutic regeneration. © 2007 Japanese Society of Nephrology.
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页码：18 / 25
页数：7
相关论文
共 48 条
  • [1] Folkman J., Tumor angiogenesis: Therapeutic implications, N Engl J Med, 285, pp. 1182-86, (1971)
  • [2] Asahara T., Murohara T., Sullivan A., Silver M., Van Der Zee R., Li T., Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275, pp. 964-7, (1997)
  • [3] Shi Q., Rafii S., Wu M.H., Wijelath E.S., Yu C., Ishida A., Evidence for circulating bone marrow-derived endothelial cells, Blood, 92, pp. 362-7, (1998)
  • [4] Folkman J., Shing Y., Angiogenesis, J Biol Chem, 267, pp. 931-4, (1992)
  • [5] Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization, Circ Res, 85, pp. 221-8, (1999)
  • [6] Gill M., Dias S., Hattori K., Rivera M.L., Hicklin D., Witte L., Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells, Circ Res, 88, pp. 167-74, (2001)
  • [7] Asahara T., Takahashi T., Masuda H., Kalka C., Chen D., Iwaguro H., VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells, Embo J, 18, pp. 3964-72, (1999)
  • [8] Iwaguro H., Yamaguchi J., Kalka C., Murasawa S., Masuda H., Hayashi S., Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration, Circulation, 105, pp. 732-8, (2002)
  • [9] Kalka C., Masuda H., Takahashi T., Kalka-Moll W.M., Silver M., Koarnoy M., Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization, Proc Natl Acad Sci U S a, 97, pp. 3422-27, (2000)
  • [10] Schatteman G.C., Hanlon H.D., Jiao C., Dodds S.G., Christy B.A., Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice, J Clin Invest, 106, pp. 571-8, (2000)
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