miR-485-5p alleviates obstructive sleep apnea syndrome with hypertension by inhibiting PI3K/AKT signaling pathway via downregulating HIF3A expression

被引:0
作者
Yan Xu
Tao Hu
Huizhen Ding
Yi Yuan
Rui Chen
机构
[1] The Second Affiliated Hospital of Soochow University,Department of Respiratory
[2] The Affiliated Hospital of Yangzhou University,Department of Respiratory
[3] Jiangsu University,Institute of Life Sciences
来源
Sleep and Breathing | 2023年 / 27卷
关键词
Obstructive sleep apnea syndrome, Pulmonary aortic hypertension (PAH); miR-485-5p; PI3K/Akt/HIF3A; Signaling pathway;
D O I
暂无
中图分类号
学科分类号
摘要
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页码:109 / 119
页数:10
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[1]  
Maspero C(2015)Obstructive sleep apnea syndrome: a literature review Minerva Stomatol 64 97-109
[2]  
Yaggi HK(2005)Obstructive sleep apnea as a risk factor for stroke and death N Engl J Med 353 2034-2041
[3]  
Gonzaga C(2015)Obstructive sleep apnea, hypertension and cardiovascular diseases J Hum Hypertens 29 705-712
[4]  
Li J(2016)Progress in research on obstructive sleep apnea syndrome with hypertension Zhong Nan Da Xue Xue Bao Yi Xue Ban 41 212-217
[5]  
Mohr AM(2015)Overview of microRNA biology Semin Liver Dis 35 3-11
[6]  
Mott JL(2017)MicroRNA therapeutics: towards a new era for the management of cancer and other diseases Nat Rev Drug Discov 16 203-222
[7]  
Rupaimoole R(2020)Micro-RNA analysis in pulmonary arterial hypertension: current knowledge and challenges JACC Basic Transl Sci 5 1149-1162
[8]  
Slack FJ(2020)MicroRNA profile of cardiovascular risk in patients with obstructive sleep apnea Respiration 99 1122-1128
[9]  
Santos-Ferreira CA(2017)Identification of MicroRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (polypyrimidine tract binding protein) and pyruvate kinase M2 Circulation 136 2451-2467
[10]  
Santamaria-Martos F(2019)MicroRNA-150 relieves vascular remodeling and fibrosis in hypoxia-induced pulmonary hypertension Biomed Pharmacother 109 1740-1749