Dosage compensation of Z sex chromosome genes in avian fibroblast cells

被引：0
作者：
Ruslan Deviatiiarov
Hiroki Nagai
Galym Ismagulov
Anastasia Stupina
Kazuhiro Wada
Shinji Ide
Noriyuki Toji
Heng Zhang
Woranop Sukparangsi
Sittipon Intarapat
Oleg Gusev
Guojun Sheng
机构：
[1] Kumamoto University,International Research Center for Medical Sciences
[2] Kazan Federal University,Regulatory Genomics Research Center, Institute of Fundamental Medicine and Biology
[3] Juntendo University,Graduate School of Medicine
[4] Life Improvement by Future Technologies Institute,Department of Biological Sciences, Faculty of Science
[5] Hokkaido University,Graduate School of Life Science
[6] Kumamoto City Zoo and Botanical Garden,Department of Biology, Faculty of Science
[7] Hokkaido University,Faculty of Science
[8] Burapha University,undefined
[9] Mahidol University,undefined
来源：
Genome Biology | / 24卷
关键词：
Birds; Sex chromosome; Dosage compensation; Sex determination; Fibroblast; CAGE (cap analysis of gene expression); TSS (transcription start site); CASI (cell autonomous sex identity); RPS6 (ribosomal protein S6);
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摘要：
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quantitative method and analyze transcriptional activities of male and female fibroblast cells from seven bird species. Our data indicate that three fourths of chrZ genes are strictly compensated across Aves, similar to mammalian chrX. We also present a complete list of non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a conserved sex-dimorphic gene in birds.
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