Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

被引：0
|
作者：
Jacqueline C Mitchell
Remy Constable
Eva So
Caroline Vance
Emma Scotter
Leanne Glover
Tibor Hortobagyi
Eveline S. Arnold
Shuo-Chien Ling
Melissa McAlonis
Sandrine Da Cruz
Magda Polymenidou
Lino Tessarolo
Don W Cleveland
Christopher E Shaw
机构：
[1] Institute of Psychiatry,King’s Centre for Neurodegeneration Research, Kings College London, Department of Basic and Clinical Neurosciences
[2] Psychology and Neuroscience,Ludwig Institute for Cancer Research and Department of Molecular Medicine
[3] Centre for Ultrastructural Imaging,undefined
[4] Kings College London,undefined
[5] University of California at San Diego,undefined
[6] Mouse Cancer Genetics Program,undefined
[7] National Cancer Institute – Frederick,undefined
[8] Present address: Neurogenetics Branch,undefined
[9] NINDS,undefined
[10] National Institutes of Health,undefined
[11] Present address: Institute of Molecular Life Sciences,undefined
[12] University of Zurich,undefined
来源：
Acta Neuropathologica Communications | / 3卷
关键词：
TDP-43; Amyotrophic lateral sclerosis; Mouse;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
    Mitchell, Jacqueline C.
    Constable, Remy
    So, Eva
    Vance, Caroline
    Scotter, Emma
    Glover, Leanne
    Hortobagyi, Tibor
    Arnold, Eveline S.
    Ling, Shuo-Chien
    McAlonis, Melissa
    Da Cruz, Sandrine
    Polymenidou, Magda
    Tessarolo, Lino
    Cleveland, Don W.
    Shaw, Christopher E.
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2015, 3 : 36
  • [2] Als-linked mutant SOD1 affects the biochemical properties of TDP-43
    Kim, J. -S.
    Choi, S. -J.
    Jeon, G. S.
    Kim, K. Y.
    Kim, S. J.
    Seong, S. -Y.
    Sung, J. -J.
    JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 337 - 338
  • [3] ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
    Horiuchi, Mai
    Watanabe, Seiji
    Komine, Okiru
    Takahashi, Eiki
    Kaneko, Kumi
    Itohara, Shigeyoshi
    Shimada, Mayuko
    Ogi, Tomoo
    Yamanaka, Koji
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2024, 12 (01):
  • [4] Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology
    Ash, Peter E. A.
    Dhawan, Uma
    Boudeau, Samantha
    Lei, Shuwen
    Carlomagno, Yari
    Knobel, Mark
    Al Mohanna, Louloua F. A.
    Boomhower, Steven R.
    Newland, M. Christopher
    Sherr, David H.
    Wolozin, Benjamin
    TOXICOLOGICAL SCIENCES, 2019, 167 (01) : 105 - 115
  • [5] ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
    Arnold, Eveline S.
    Ling, Shuo-Chien
    Huelga, Stephanie C.
    Lagier-Tourenne, Clotilde
    Polymenidou, Magdalini
    Ditsworth, Dara
    Kordasiewicz, Holly B.
    McAlonis-Downes, Melissa
    Platoshyn, Oleksandr
    Parone, Philippe A.
    Da Cruz, Sandrine
    Clutario, Kevin M.
    Swing, Debbie
    Tessarollo, Lino
    Marsala, Martin
    Shaw, Christopher E.
    Yeo, Gene W.
    Cleveland, Don W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) : E736 - E745
  • [6] Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
    Tong, Jianbin
    Huang, Cao
    Bi, Fangfang
    Wu, Qinxue
    Huang, Bo
    Liu, Xionghao
    Li, Fang
    Zhou, Hongxia
    Xia, Xu-Gang
    EMBO JOURNAL, 2013, 32 (13): : 1917 - 1926
  • [7] TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
    Wegorzewska, Iga
    Bell, Shaughn
    Cairns, Nigel J.
    Miller, Timothy M.
    Baloh, Robert H.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (44) : 18809 - 18814
  • [8] An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
    Feneberg, Emily
    Gordon, David
    Thompson, Alexander G.
    Finelli, Mattea J.
    Dafinca, Ruxandra
    Candalija, Ana
    Charles, Philip D.
    Mager, Imre
    Wood, Matthew J.
    Fischer, Roman
    Kessler, Benedikt M.
    Gray, Elizabeth
    Turner, Martin R.
    Talbot, Kevin
    NEUROBIOLOGY OF DISEASE, 2020, 144
  • [9] TDP-43 Mutant Transgenic Mice Develop Features of ALS and Frontotemporal Lobar Degeneration
    Wegorzewska, Iga
    Bell, Shaughn
    Cairns, Nigel
    Miller, Timothy
    Baloh, Robert
    NEUROLOGY, 2010, 74 (09) : A98 - A98
  • [10] ALS-linked TDP-43 inclusions dysregulate astroglial noradrenergic signalling and metabolism
    Horvat, A.
    Velebit, J.
    Smolic, T.
    Mihevc, S. Prpar
    Rogelj, B.
    Zorec, R.
    Vardjan, N.
    FEBS OPEN BIO, 2021, 11 : 467 - 467
12345