Phenobarbital Modifies Antitumor Effect of Cyclophosphamide Depending on the Type of Tumor Cell Death Caused by It

被引：0

作者：

V. I. Kaledin

V. P. Nikolin

T. Yu. Baimak

M. R. Galyamova

N. A. Popova

E. M. Andreeva

机构：

[1] Institute of Cytology and Genetics,Siberian Branch of Russian Academy of Sciences

[2] Novosibirsk State University,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2003年 / 135卷

关键词：

transplanted tumors; cyclophosphamide; phenobarbital; apoptosis; necrosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Antitumor effect of cyclophosphamide on LS and P388 tumors is realized via apoptosis and on HA-1 and Krebs-2 tumors resistant to apoptosis via necrosis of tumor cells. Phenobarbital induction of cyclophosphamide-metabolizing enzymes decreases and cimetidine inhibition potentiates the effect of cyclophosphamide on LS and P388 cells and does not modulate the effect on HA-1 and Krebs-2 cells. Presumably, apoptosis and necrosis of tumor cell are induced by different cyclophosphamide metabolites.

引用

页码：289 / 292

页数：3

共 50 条

[41] Effect of valproic acid, a histone deacetylase inhibitor, on cell death and molecular changes caused by low-dose irradiation
Zaskodova, Darina
Rezacova, Martina
Vavrova, Jirina
Vokurkova, Doris
Tichy, Ales
SIGNAL TRANSDUCTION PATHWAYS, PT B: STRESS SIGNALING AND TRANSCRIPTIONAL CONTROL, 2006, 1091 : 385 - 398
[42] Tumor-specific Cytotoxicity and Type of Cell Death Induced by Sodium 5,6-Benzylidene-L-ascorbate
Kishino, Kaori
Hashimoto, Ken
Amano, Osamu
Kochi, Mutsuyuki
Liu, Wk
Sakagami, Hiroshi
ANTICANCER RESEARCH, 2008, 28 (5A) : 2577 - 2584
[43] A reduction of recipient regulatory T cells by cyclophosphamide contributes to an anti-tumor effect of nonmyeloablative allogeneic stem cell transplantation in mice
Takeuchi, Ario
Eto, Masatoshi
Yamada, Hisakata
Tatsugami, Katsunori
Naito, Seiji
Yoshikai, Yasunobu
INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (02) : 365 - 376
[44] Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells
Davis, MA
Flaws, JA
Young, M
Collins, K
Colburn, NH
TOXICOLOGICAL SCIENCES, 2000, 53 (01) : 48 - 55
[45] Effect of Nitric Oxide Donor, a Modulator of Tumor Drug Resistance, on Cell Death and p53 Protein Expression
Rajewskaya, T. A.
Goncharova, S. A.
Konovalova, N. P.
Terent'ev, A. A.
Lapshina, M. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2009, 147 (04) : 421 - 423
[46] Effect of Nitric Oxide Donor, a Modulator of Tumor Drug Resistance, on Cell Death and p53 Protein Expression
T. A. Rajewskaya
S. A. Goncharova
N. P. Konovalova
A. A. Terent’ev
M. A. Lapshina
Bulletin of Experimental Biology and Medicine, 2009, 147 : 421 - 423
[47] Anti-Tumor Effect of a Novel DOX/GA-CdTe QD was Mediated by Apoptotic and Autophagic Cell Death
Zuo, Huaqin
Wang, Fan
Zhou, Di
Zhou, Yi
Chen, Bing
Ouyang, Jian
Xu, Peipei
NANO, 2017, 12 (01)
[48] Activation of the MDA-5-IPS-1 Viral Sensing Pathway Induces Cancer Cell Death and Type I IFN-Dependent Antitumor Immunity
Yu, Xiaofei
Wang, Hongxia
Li, Xia
Guo, Chunqing
Yuan, Fang
Fisher, Paul B.
Wang, Xiang-Yang
CANCER RESEARCH, 2016, 76 (08) : 2166 - 2176
[49] Ganoderma Lucidum Spore Oil enhances the effect of cyclophosphamide via inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice
Jiang, Zhaojian
Cai, Hongfei
Yuan, Cheng
Cao, Lin
Xu, Wendong
Han, Yaming
Zhang, Qin
Li, Jing
Wang, Qin
Liu, Juyan
JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2024, 44 (04) : 652 - 659
[50] Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model
Ma, Yi-Shih
Weng, Shu-Wen
Lin, Meng-Wei
Lu, Chi-Cheng
Chiang, Jo-Hua
Yang, Jai-Sing
Lai, Kuang-Chi
Lin, Jing-Pin
Tang, Nou-Ying
Lin, Jaung-Geng
Chung, Jing-Gung
FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (05) : 1271 - 1278

← 1 2 3 4 5 →