Phenobarbital Modifies Antitumor Effect of Cyclophosphamide Depending on the Type of Tumor Cell Death Caused by It

被引：0
|
作者：
V. I. Kaledin
V. P. Nikolin
T. Yu. Baimak
M. R. Galyamova
N. A. Popova
E. M. Andreeva
机构：
[1] Institute of Cytology and Genetics,Siberian Branch of Russian Academy of Sciences
[2] Novosibirsk State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷
关键词：
transplanted tumors; cyclophosphamide; phenobarbital; apoptosis; necrosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antitumor effect of cyclophosphamide on LS and P388 tumors is realized via apoptosis and on HA-1 and Krebs-2 tumors resistant to apoptosis via necrosis of tumor cells. Phenobarbital induction of cyclophosphamide-metabolizing enzymes decreases and cimetidine inhibition potentiates the effect of cyclophosphamide on LS and P388 cells and does not modulate the effect on HA-1 and Krebs-2 cells. Presumably, apoptosis and necrosis of tumor cell are induced by different cyclophosphamide metabolites.
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页码：289 / 292
页数：3
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