Neuroimaging in bipolar disorder: A critical review of current findings

被引：78
作者：
Keener M.T. [1 ]
Phillips M.L. [1 ]
机构：
[1] Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
来源：
Current Psychiatry Reports | 2007年 / 9卷 / 6期
关键词：
Bipolar Disorder; Diffusion Tensor Imaging; Emotion Processing; Executive Control; Biol Psychiatry;
D O I：
10.1007/s11920-007-0070-2
中图分类号：
学科分类号：
摘要：
Bipolar I disorder (BPI) is among the top 10 most debilitating illnesses globally. In this critical review, we first review recent functional neuroimaging findings in two core domains of pathology in BPI: emotion processing and executive control. These abnormalities in core domains represent potential endophenotypes of the illness. We then show that an emerging number of studies have demonstrated that neuroimaging can help to identify endophenotypic markers whose identification would help to clarify diagnosis and discriminate the depression in BPI from that of unipolar depression and identify at-risk individuals who will subsequently develop the illness (to facilitate early intervention). We end by reviewing the new directions in neuroimaging in BPI, including studies of children with bipolar disorder, potential medication effects, and the use of newer neuroimaging techniques to help us achieve the previously mentioned goals of improving BPI patients' mental well-being. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：512 / 520
页数：8
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