Objectives: To compare the efficacy of three suture materials, i.e., poliglecaprone 25, polyglactin 910, and polyamide, as subcuticular skin stitches in post-cesarean women. Study Design: This was a randomized clinical trial. Population: The study was conducted in the department of obstetrics and gynecology of a tertiary institute, LTMMC, Sion, Mumbai, India. Only those women undergoing emergency cesarean section were included. Methods: The study was conducted in the department of obstetrics and gynecology of a tertiary institute, LTMMC, Sion, Mumbai, India. 90 women undergoing emergency cesarean section were included and divided into three groups. In group 1, poliglecaprone 25 was used as subcuticular skin stitches; in group 2, polyglactin 910 was used as subcuticular skin stitches; and in group 3, polyamide was used as subcuticular skin stitches. Results: Thirty percentage of the patients in group 3 had discomfort on day 10, while it was only 3.3% in group 1. In group 1, 6.6% patients had swelling and indurations, while it was 33.3% in group 2 on day 4. Wound dehiscence was present in 3.3% patients in group 1, 26.6% in group 2, and 6.6% in group 3. Regarding wound healing, 93.3% patients had excellent wound healing in group 1, 66.6% in group 2, and 86.6% in group 3. Conclusions: The results were almost similar with poliglecaprone and polyamide, except for discomfort which was present more in patients in group 3. © Federation of Obstetric & Gynecological Societies of India 2013.