Spotlight on Oxcarbazepine in Epilepsy

被引：0
作者：
Lynne M. Bang
Karen L. Goa
机构：
[1] Adis International Ltd,
来源：
CNS Drugs | 2004年 / 18卷
关键词：
Adjunctive Therapy; Oxcarbazepine; Anticonvulsant Activity; Partial Onset Seizure; Major Active Metabolite;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxcarbazepine (Trileptal®, Timox®) is structurally related to carbamazepine and has anticonvulsant activity. Studies suggest that the anticonvulsant activity of oxcarbazepine is mediated via the blocking of neuronal ion channels.
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页码：57 / 61
页数：4
相关论文
共 90 条
[1]  
Tecoma ES(1999)Oxcarbazepine Epilepsia 40 S37-46
[2]  
Wamil AW(1994)Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures Eur J Pharmacol 271 301-8
[3]  
Schmutz M(1995)Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system II: modulation of high-voltage-activated calcium currents Epilepsia 36 997-1002
[4]  
Portet C(1995)Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system I: modulation of corticostriatal synaptic transmission Epilepsia 36 990-6
[5]  
Stefani A(1993)Memory and psychomotor effects of oxcarbazepine in healthy human volunteers Eur J Clin Pharmacol 44 529-33
[6]  
Pisani M(1995)Cognitive function and anticonvulsant therapy: effect of monotherapy in epilepsy Acta Neuro Scand 92 19-27
[7]  
De Murtas P(1999)The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy Pediatrics 103 588-93
[8]  
Calabresi M(1994)Pharmacokinetics of oxcarbazepine as add-on therapy in epileptic children [abstract] Epilepsia 8 119-88
[9]  
De Murtas A(2001)Multicenter study of oxcarbazepine pharmacokinetics and tolerability in children with refractory epilepsy [abstract no. P14] Ann Neurol 50 S104-23
[10]  
Stefani HV(1992)Oxcarbazepine: a review of its pharmacology and therapeutic potential in epilepsy: trigeminal neuralgia and affective disorders Drugs 43 873-85
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