Characterization of venlafaxine hydrochloride and compatibility studies with pharmaceutical excipients

被引：0
|
作者：
L. S. Bernardi
P. R. Oliveira
F. S. Murakami
M. A. S. Silva
S. H. M. Borgmann
S. G. Cardoso
机构：
[1] Universidade Federal de Santa Catarina,Laboratório de Controle de Qualidade
来源：
Journal of Thermal Analysis and Calorimetry | 2009年 / 97卷
关键词：
Venlafaxine hydrochloride; Solid-state characterization; Compatibility studies;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The thermal analytical study of venlafaxine hydrochloride, a third generation antidepressant, was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The DSC curves have shown a sharp endothermic event at 211 °C and TG demonstrated a single stage of mass loss between 254 and 283 °C. Solid-state characterization was carried out by DRIFT, SEM, and XRPD demonstrating the drug physicochemical properties including crystallinity. Drug-excipient compatibility studies investigated by DSC have shown a possible physical interaction of the drug with magnesium stearate, microcrystalline cellulose and starch. Nevertheless, these results where not confirmed by DRIFT and SEM analyses.
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