Effect of Okadaic Acid, a Protein Phosphatase Inhibitor, on Heat Stress-Induced HSP72 Synthesis and Thermotolerance

被引：0

作者：

Marie Joyeux

Claire Arnaud

Marie-Jeanne Richard

Derek M. Yellon

Pierre Demenge

Christophe Ribuot

机构：

[1] Laboratoire de Pharmacologie Cardiovasculaire Expérimentale-Biomolécules,Laboratoire de Biologie du stress oxydant

[2] Université Joseph Fourier,The Hatter Institute for Cardiovascular Studies

[3] U.F.R. de Pharmacie,undefined

[4] University College London Hospitals & Medical School,undefined

[5] Laboratoire de Pharmacologie Cardiovasculaire Expérimentale-Biomolécules,undefined

来源：

Cardiovascular Drugs and Therapy | 2000年 / 14卷

关键词：

heat stress; heat stress protein; okadaic acid; protein phosphatases; smooth muscle cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Heat stress proteins (HSPs), in particular HSP72, seem to play a major role in cell protection against lethal stresses such as hyperthermia or ischemia. HSP synthesis is negatively regulated by protein phosphatases, which are implicated in dephosphorylation processes. In the present study, we have investigated the effect of okadaic acid (OA, a protein phosphatase inhibitor) on heat stress-induced HSP72 synthesis and thermotolerance in smooth muscle cells (SMC).

引用

页码：441 / 446

页数：5

共 20 条

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Demenge, P
Ribuot, C
CARDIOVASCULAR DRUGS AND THERAPY, 2000, 14 (04) : 441 - 446
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[8] Saikosaponin-D Attenuates Heat Stress-Induced Oxidative Damage in LLC-PK1 Cells by Increasing the Expression of Anti-Oxidant Enzymes and HSP72
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[9] Effect of low-intensity resistance training with heat stress on the HSP72, anabolic hormones, muscle size, and strength in elderly women
Yoon, Sung Jin
Lee, Moon Jin
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AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2017, 29 (05) : 977 - 984
[10] Effect of low-intensity resistance training with heat stress on the HSP72, anabolic hormones, muscle size, and strength in elderly women
Sung Jin Yoon
Moon Jin Lee
Hyo Min Lee
Jin Seok Lee
Aging Clinical and Experimental Research, 2017, 29 : 977 - 984

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