Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

被引：34
作者：
Akca K. [1 ,2 ]
Sarac E. [3 ]
Baysal U. [4 ]
Fanuscu M. [5 ]
Chang T.-L. [6 ]
Cehreli M. [7 ]
机构：
[1] Division of Restorative Dentistry, Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLAc School of Dentistry
[2] Department of Prosthodontics, Faculty of Dentistry, Hacettepe University, Ankara
[3] Private Practice, Obstetrics and Gynecology, Ankara
[4] Department of Electrical and Electronics Engineering, Hacettepe University, Ankara
[5] Division of Restorative Dentistry, Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry
[6] Division of Advanced Prosthodontics, Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry
[7] Prosthodontics, CosmORAL Oral and Dental Health Polyclinics, Ankara
来源：
Head & Face Medicine | / 3卷 / 1期
关键词：
Trabecular Thickness; Titanium Implant; Trabecular Separation; Pulse Electromagnetic Field; Proximal Metaphyses;
D O I：
10.1186/1746-160X-3-28
中图分类号：
学科分类号：
摘要：
Background: Osteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats. Methods: Fifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed en bloc and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 μm wide peri-implant volume of interest (VOI). Results: Mean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (P < .05). Differences in trabecular-thickness and separation around implants in all groups were similar (P > .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (P < .05). Conclusion: Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.
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