ETV5 transcriptionally activates TGFβ1 and promotes cancer cell invasion and migration of NSCLC

被引：0
作者：
Dan Li
Yanwei Shen
Hui Ren
Li Wang
Jin Yang
Yuan Wang
机构：
[1] The First Affiliated Hospital of Xi’an Jiaotong University,Department of Respiratory and Critical Care Medicine
[2] Shaanxi Provincial People’s Hospital,Department of Surgical Oncology
[3] The First Affiliated Hospital of Xi’an Jiaotong University,Department of Medical Oncology
[4] The First Affiliated Hospital of Xi’an Jiaotong University,Department of Medical Imaging
来源：
Journal of Molecular Histology | 2023年 / 54卷
关键词：
NSCLC; ETV5; TGFβ; Invasion; Migration; Prognosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The morbidity and mortality of NSCLC remains high worldwide. However, the molecular mechanisms of NSCLC still largely unclear. Ets variant 5 (ETV5) is a transcription factor that found to be overexpressed in multiple cancers. However, the role of ETV5 in NSCLC remains unknown. We aim to explore the role and mechanisms of ETV5 in NSCLC development. The expression of ETV5 was evaluated in NSCLC tissues and cell lines. ETV5 overexpressing and downregulation cell lines were established according to the endogenous expression of ETV5. Functional studies were performed by transwell assay. The downstream targets of ETV5 were screened by PCR array and were confirmed by luciferase reporter assay. We found that overexpression of ETV5 indicates worse prognosis of NSCLC patients. Elevated ETV5 expression promotes NSCLC cell invasion and migration via transcriptional activates of TGFβ1. Therefore, ETV5/TGFβ signaling may serve as a therapeutic target for NSCLS patients.
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页码：419 / 426
页数：7
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