Biomolecular condensates: organizers of cellular biochemistry

被引：0
|
作者：
Salman F. Banani
Hyun O. Lee
Anthony A. Hyman
Michael K. Rosen
机构：
[1] University of Texas Southwestern Medical Center,Department of Biophysics and Howard Hughes Medical Institute
[2] Max Planck Institute of Molecular Cell Biology and Genetics,undefined
来源：
Nature Reviews Molecular Cell Biology | 2017年 / 18卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In addition to canonical membrane-bound organelles, eukaryotic cells contain numerous membraneless compartments, or biomolecular condensates, that concentrate specific collections of proteins and nucleic acids.Biomolecular condensates behave as phase-separated liquids and are enriched in multivalent molecules.Theoretical concepts from polymer and physical chemistry regarding the behaviour of multivalent molecules provide a mechanistic framework that can explain a wide range of cellular behaviours exhibited by biomolecular condensates, including plausible mechanisms by which their assembly, composition, and biochemical and cellular functions can be regulated.
引用
收藏
页码：285 / 298
页数：13
相关论文
共 50 条
  • [1] Biomolecular condensates: organizers of cellular biochemistry
    Banani, Salman F.
    Lee, Hyun O.
    Hyman, Anthony A.
    Rosen, Michael K.
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2017, 18 (05) : 285 - 298
  • [2] Influence of cellular crowding on biomolecular condensates
    Pyo, Andrew G. T.
    Wingreen, Ned S.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 492A - 492A
  • [3] Biomolecular condensates in cellular stress and disease
    Alberti, S.
    FEBS OPEN BIO, 2024, 14 : 59 - 59
  • [4] Programmable synthetic biomolecular condensates for cellular control
    Dai, Yifan
    Farag, Mina
    Lee, Dongheon
    Zeng, Xiangze
    Kim, Kyeri
    Son, Hye-in
    Guo, Xiao
    Su, Jonathan
    Peterson, Nikhil
    Mohammed, Javid
    Ney, Max
    Shapiro, Daniel Mark
    Pappu, Rohit V.
    Chilkoti, Ashutosh
    You, Lingchong
    NATURE CHEMICAL BIOLOGY, 2023, 19 (04) : 518 - +
  • [5] Caught in the Act? Quantifying Biochemistry Inside and Outside of Biomolecular Condensates
    Wilbertz, Johannes H.
    Chao, Jeffrey A.
    BIOCHEMISTRY, 2019, 58 (03) : 142 - 143
  • [6] Biomolecular condensates regulate cellular electrochemical equilibria
    Dai, Yifan
    Zhou, Zhengqing
    Yu, Wen
    Ma, Yuefeng
    Kim, Kyeri
    Rivera, Nelson
    Mohammed, Javid
    Lantelme, Erica
    Hsu-Kim, Heileen
    Chilkoti, Ashutosh
    You, Lingchong
    CELL, 2024, 187 (21)
  • [7] Programmable synthetic biomolecular condensates for cellular control
    Yifan Dai
    Mina Farag
    Dongheon Lee
    Xiangze Zeng
    Kyeri Kim
    Hye-in Son
    Xiao Guo
    Jonathan Su
    Nikhil Peterson
    Javid Mohammed
    Max Ney
    Daniel Mark Shapiro
    Rohit V. Pappu
    Ashutosh Chilkoti
    Lingchong You
    Nature Chemical Biology, 2023, 19 : 518 - 528
  • [8] Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?
    Cheng, Xiaodong
    Yang, Wenli
    Lin, Wei
    Mei, Fang
    PHARMACOLOGICAL REVIEWS, 2023, 75 (05) : 979 - 1006
  • [9] Formation of Biomolecular Condensates: Regulation of Embryogenesis at the Cellular Level
    M. A. Tikhomirova
    E. V. Sheval
    Russian Journal of Developmental Biology, 2021, 52 : 65 - 74
  • [10] Formation of Biomolecular Condensates: Regulation of Embryogenesis at the Cellular Level
    Tikhomirova, M. A.
    Sheval, E. V.
    RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY, 2021, 52 (02) : 65 - 74
12345