Temperature Dependence of Bimolecular Reactions Associated with Molecular Mobility in Lyophilized Formulations

被引：0

作者：

Sumie Yoshioka

Yukio Aso

Shigeo Kojima

机构：

[1] National Institute of Health Sciences,

[2] National Institute of Health Sciences,undefined

来源：

Pharmaceutical Research | 2000年 / 17卷

关键词：

acetyl transfer; hydrolysis; lyophilized formulation; temperature dependence; molecular mobility;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. We studied the temperature dependence of acetyltransfer between aspirin and sulfadiazine, a bimolecular reaction, inlyophilized formulations at temperatures near the glass transitiontemperature (Tg) and NMR relaxation-based critical mobilitytemperature (Tmc), to further understand the effect of molecularmobility on chemical degradation rates in solid pharmaceutical formulations.The temperature dependence of the hydrolysis rates of aspirin andcephalothin in lyophilized formulations was also studied as a model ofbimolecular reactions in which water is a reactant.

引用

页码：925 / 929

页数：4

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[1] Temperature dependence of bimolecular reactions associated with molecular mobility in lyophilized formulations
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[2] Temperature- and glass transition temperature-dependence of bimolecular reaction rates in lyophilized formulations described by the Adam-Gibbs-Vogel equation
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[3] The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature
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[4] The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature
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[5] A quantitative assessment of the significance of molecular mobility as a determinant for the stability of lyophilized insulin formulations
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[9] Molecular mobility of protein in lyophilized formulations linked to the molecular mobility of polymer excipients, as determined by high resolution 13C solid-state NMR
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