Roles of IDH1/2 and TET2 mutations in myeloid disorders

被引：0
作者：
Satoshi Inoue
François Lemonnier
Tak W. Mak
机构：
[1] University Health Network,The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Ontario Cancer Institute
来源：
International Journal of Hematology | 2016年 / 103卷
关键词：
IDH1; TET2; MDS; AML; DNA damage; DNA repair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase ‘ten–eleven translocation 2’ (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability. The clinical relevance of these findings and their potential application in novel therapeutic strategies is also discussed.
引用
收藏
页码：627 / 633
页数：6
相关论文
共 317 条
[21]  
Grauman PV(2004)Identification of a dehydrogenase acting on Biochem J 381 35-16854
[22]  
Mar BG(2004)-2-hydroxyglutarate Proc Natl Acad Sci USA 101 16849-311
[23]  
Busque L(2010)A gene encoding a putative FAD-dependent Science 330 336-303
[24]  
Patel JP(2015)-2-hydroxyglutarate dehydrogenase is mutated in Cell Metab 22 304-469
[25]  
Figueroa ME(2015)-2-hydroxyglutaric aciduria Cell Metab 22 291-483
[26]  
Vasanthakumar A(2011)IDH2 mutations in patients with EMBO Rep 12 463-2049
[27]  
Provost S(2012)-2-hydroxyglutaric aciduria Nature 483 479-30
[28]  
Hamilou Z(2012)Hypoxia induces production of Genes Dev 26 2038-488
[29]  
Cimmino L(2011)-2-hydroxyglutarate Cancer Cell 19 17-659
[30]  
Dawlaty MM(2012)Hypoxia-mediated increases in Nature 483 484-184
12345678910