Roles of IDH1/2 and TET2 mutations in myeloid disorders

被引：0
作者：
Satoshi Inoue
François Lemonnier
Tak W. Mak
机构：
[1] University Health Network,The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Ontario Cancer Institute
来源：
International Journal of Hematology | 2016年 / 103卷
关键词：
IDH1; TET2; MDS; AML; DNA damage; DNA repair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase ‘ten–eleven translocation 2’ (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability. The clinical relevance of these findings and their potential application in novel therapeutic strategies is also discussed.
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页码：627 / 633
页数：6
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[1]  
Shih AH(2012)The role of mutations in epigenetic regulators in myeloid malignancies Nat Rev Cancer 12 599-612
[2]  
Abdel-Wahab O(2014)Age-related mutations associated with clonal hematopoietic expansion and malignancies Nat Med 20 1472-1478
[3]  
Patel JP(2012)Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters Blood 120 1466-1469
[4]  
Levine RL(2014)Age-related clonal hematopoiesis associated with adverse outcomes N Engl J Med. 371 2488-2498
[5]  
Xie M(2012)Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis Nat Genet 44 1179-1181
[6]  
Lu C(2013)Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia N Engl J Med. 368 2059-2074
[7]  
Wang J(2015)TET1 is a tumor suppressor of hematopoietic malignancy Nat Immunol 16 653-662
[8]  
McLellan MD(2015)Acute loss of TET function results in aggressive myeloid cancer in mice Nat Commun. 6 10071-1704
[9]  
Johnson KJ(2015)Combined loss of Tet1 and Tet2 promotes B cell, but not myeloid malignancies, in mice Cell Rep. 13 1692-1303
[10]  
Wendl MC(2011)Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine Science 333 1300-434
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