Genetic influences on rheumatoid arthritis in african americans

被引：0
作者：
Laura B. Hughes
Larry W. Moreland
S. Louis Bridges
机构：
[1] University of Alabama at Birmingham,Division of Clinical Immunology and Rheumatology
来源：
Immunologic Research | 2002年 / 26卷
关键词：
Rheumatoid arthritis; Genetics; African American; Caucasian; Methotrexate; Tumor necrosis factor inhibitors;
D O I：
暂无
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学科分类号：
摘要：
Rheumatoid arthritis is a common autoimmune disease characterized by inflammation of the synovial membrane of diarthrodial joints, which often leads to joint damage and disability. There are known associations between major histocompatibility complex class II alleles and susceptibility to rheumatoid arthritis and its severity in Caucasians. African Americans, an admixed population in the United States, has been underrepresented in genetic studies of the susceptibility and severity of rheumatoid arthritis. With the advent of biologic agents, which target specific molecules of the immune system (e.g., tumor necrosis factor, interleukin-1), biologic markers of treatment response in Caucasians and in African Americans would be clinically useful.
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页码：15 / 26
页数：11
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