Evaluation the effects of N-acetyl cysteine on pericardial adhesions in experimental rabbit models

被引：0

作者：

Shahzamani M. ^{[1
]}

Ghods K. ^{[2
]}

Abedi G. ^{[3
]}

Shahzamani P. ^{[3
]}

Mirhoseini M. ^{[4
]}

Motamedi M. ^{[5
]}

机构：

[1] Department of Cardiovascular Surgery, Isfahan University of Medical Sciences, Isfahan

[2] Department of Cardiovascular Surgery, Semnan University of Medical Sciences, Semnan

[3] Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran

[4] Department of Cardiovascular Surgery, Shaheed Modarres Hospital, Shaheed Beheshti University of Medical Sciences, Tehran

[5] Najafabad Azad University, Isfahan

来源：

Comparative Clinical Pathology | 2015年 / 24卷 / 5期

关键词：

Anti-inflammatory agents; N-acetyl cysteine; Pericardial adhesions; Re-sternotomy surgery;

D O I：

10.1007/s00580-014-2016-5

中图分类号：

学科分类号：

摘要：

Adhesions are one of the main causes of re-sternotomy complications. In this study, we evaluated the potential of N-acetyl cysteine irrigation in reducing or preventing pericardial adhesions after cardiac surgery in rabbits. Thirty rabbits were allocated randomly into two groups. Group C served as the control, and group N was the treatment group. After anaesthesia, sternotomy and opening a pericardial flap, the pericardial cavity was irrigated with 1 ml/kg saline (group C) or with 100 mg/kg of N-acetyl cysteine (group N). After 2 months, the sternum was re-opened and the site of operation evaluated for macroscopic and microscopic changes. Macroscopic evaluation revealed 40 % (n = 6) with grade 1, 46 % (n = 7) with grade 2, and 13.3 % (n = 3) with grade 3 adhesions in group C. In group N, there were 60 % (n = 9) with grade 0 (no adhesions) and 40 % (n = 6) with grade 1 adhesions. N-acetyl cysteine irrigation appears to significantly reduce macroscopic adhesions, and there was also a trend towards a reduced reaction microscopically; therefore, further studies are warranted. © 2014, Springer-Verlag London.

引用

页码：985 / 988

页数：3

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