Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial

被引：0

作者：

Philippe Bégin

Jeannie Callum

Nancy M. Heddle

Richard Cook

Michelle P. Zeller

Alan Tinmouth

Dean A. Fergusson

Melissa M. Cushing

Marshall J. Glesby

Michaël Chassé

Dana V. Devine

Nancy Robitalle

Renée Bazin

Nadine Shehata

Andrés Finzi

Allison McGeer

Damon C. Scales

Lisa Schwartz

Alexis F. Turgeon

Ryan Zarychanski

Nick Daneman

Richard Carl

Luiz Amorim

Caroline Gabe

Martin Ellis

Bruce S. Sachais

Kent Cadogan Loftsgard

Erin Jamula

Julie Carruthers

Joanne Duncan

Kayla Lucier

Na Li

Yang Liu

Chantal Armali

Amie Kron

Dimpy Modi

Marie-Christine Auclair

Sabrina Cerro

Meda Avram

Donald M. Arnold

机构：

[1] CHU Sainte-Justine,Section of Allergy, Immunology and Rheumatology, Department of Pediatrics

[2] Université de Montréal,Department of Medicine, CHUM

[3] Sunnybrook Health Sciences Centre,Department of Laboratory Medicine and Molecular Diagnostics

[4] University of Toronto,Department of Laboratory Medicine and Pathobiology

[5] McMaster University,Department of Medicine

[6] McMaster University,McMaster Centre for Transfusion Research

[7] University of Waterloo,Department of Statistics and Actuarial Science

[8] University of Ottawa,Department of Medicine, Ottawa Hospital

[9] Ottawa Hospital Research Institute,Ottawa Hospital Centre for Transfusion Research

[10] Canadian Blood Services,Clinical Epidemiology Program

[11] Ottawa Hospital Research Institute,Department of Medicine

[12] University of Ottawa,Adjunct Scientist

[13] Canadian Blood Services,Transfusion Medicine and Cellular Therapy

[14] NewYork-Presbyterian,Department of Pathology and Laboratory Medicine

[15] Weill Cornell Medicine,Division of Infectious Diseases

[16] Weill Cornell Medical College,Department of Medicine (Critical Care)

[17] Weill Cornell Medicine,Department of Medicine

[18] University of Montreal Health Centre (CHUM),Department of Pathology and Laboratory Medicine

[19] University of Montreal,Division of Hematology and Oncology, Department of Pediatrics, CHU Sainte

[20] University of British Columbia,Justine

[21] Héma-Québec,Medical Affairs and Innovation

[22] Université de Montréal,Departments of Medicine, Laboratory Medicine and Pathobiology, Institute of Health Policy Management and Evaluation

[23] Héma-Québec,Département de Microbiologie, Infectiologie et Immunologie

[24] University of Toronto,Department of Microbiology

[25] Division of Hematology,Department of Laboratory Medicine and Pathobiology and Dalla Lana School of Public Health

[26] Mount Sinai Hospital,Department of Critical Care Medicine

[27] Canadian Blood Services,Department of Medicine, Interdepartmental Division of Critical Care

[28] Université de Montréal,Department of Health Research Methods, Evidence & Impact, Faculty of Health Sciences

[29] CHUM Research Center,Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Faculty of Medicine

[30] Sinai Health System,CHU de Québec – Université Laval Research Centre, Population Health and Optimal Health Practices Research Unit, Trauma

[31] University of Toronto, Emergency

[32] Sunnybrook Health Sciences Centre, Critical Care Medicine

[33] University of Toronto,Department of Medicine, Division of Infectious Diseases, Sunnybrook Health Sciences Centre

[34] McMaster University,Hematology Institute and Blood Bank

[35] Université Laval,Sackler School of Medicine

[36] Université Laval,Department of Computing and Software

[37] Department of Internal Medicine,Department of Community Health Sciences

[38] Sections of Hematology/Medical Oncology and Critical Care,Clinical Research Department, Centre de recherche du CHU Sainte

[39] University of Manitoba,Justine

[40] University of Toronto,undefined

[41] Hemorio,undefined

[42] Meir Medical Center,undefined

[43] Tel Aviv University,undefined

[44] New York Blood Center Enterprises,undefined

[45] McMaster University,undefined

[46] University of Calgary,undefined

[47] Centre Hospitalier Universitaire Sainte-Justine Centre,undefined

来源：

Trials | / 22卷

关键词：

Convalescent plasma; SARS-CoV-2; Coronavirus; COVID-19; Randomized controlled trial;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 582 条

[1]

Casadevall A(2020)The convalescent sera option for containing COVID-19 J Clin Invest 130 1545-1548

[2]

Pirofski L(2020)Treatment of 5 critically ill patients with COVID-19 with convalescent plasma JAMA. 323 1582-1589

[3]

Shen C(2005)Use of convalescent plasma therapy in SARS patients in Hong Kong Eur J Clin Microbiol Infect Dis 24 44-46

[4]

Wang Z(2011)Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection Clin Infect Dis 52 447-456

[5]

Zhao F(2017)Evaluation of convalescent whole blood for treating Ebola virus disease in Freetown, Sierra Leone J Inf Secur 74 302-309

[6]

Yang Y(2016)Evaluation of convalescent plasma for Ebola virus disease in Guinea N Engl J Med 374 33-42

[7]

Li J(2015)The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis J Infect Dis 211 80-90

[8]

Yuan J(2020)Indirect evidence on efficacy and safety of convalescent plasma in severe COVID-19 patients: systematic review and meta-analysis CMAJ. 192 E745-E755

[9]

Wang F(2020)Effectiveness of convalescent plasma therapy in severe COVID-19 patients Proc Natl Acad Sci 117 9490-9496

[10]

Li D(2020)Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection Chest. 158 e9-13

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