What is glaucomatous optic neuropathy?

被引：0
作者：
Toru Nakazawa
Takeo Fukuchi
机构：
[1] Tohoku University Graduate School of Medicine,Department of Ophthalmology
[2] Niigata University,Division of Opthalmology and Visual Science, Graduated School of Medical and Dental Sciences
来源：
Japanese Journal of Ophthalmology | 2020年 / 64卷
关键词：
Glaucomatous optic neuropathy; Mechanical theory; Lamina cribrosa; Axonal transport; Biomechanical theory; Vascular theory;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glaucomatous optic neuropathy (GON) is the pathohistological feature of glaucoma in the optic nerve. The pathogenesis of GON has been hypothesized, to either originate from compromised mechanical conditions at the lamina cribrosa or as associated with pathological vascular involvement. From a historical perspective, glaucoma is the degeneration of retinal ganglion cells (RGC) due to the elevation of intraocular pressure (IOP). The consensus of glaucoma treatment is generally accepted as sufficient IOP reduction. Is there an additional option to treat GON from the perspective of the vascular theory? In this section, two distinguished leaders in glaucoma research advance their views and discuss the current opinions surrounding the two theories regarding the causes of GON in primary open angle glaucoma (POAG) and normal tension glaucoma (NTG).
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页码：243 / 249
页数：6
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  • [1] Leske MC(2009)Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings Curr Opin Ophthalmol. 20 73-78
  • [2] Sugiyama T(2010)Use of laser speckle flowgraphy in ocular blood flow research Acta Ophthalmol. 88 723-729
  • [3] Araie M(2011)Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma Clin Ophthalmol. 5 1171-1176
  • [4] Riva CE(2014)Optical coherence tomography angiography of optic disc perfusion in glaucoma Ophthalmology 121 1322-1332
  • [5] Schmetterer L(2018)Reproducibility of macular vessel density calculations via imaging with two different swept-source optical coherence tomography angiography systems Transl Vis Sci Technol. 7 31-7996
  • [6] Orgul S(2014)Laser speckle and hydrogen gas clearance measurements of optic nerve circulation in albino and pigmented rabbits with or without optic disc atrophy Invest Ophthalmol Vis Sci. 55 7991-15
  • [7] Aizawa N(2013)Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits Exp Eye Res. 108 10-8309
  • [8] Yokoyama Y(2012)Anterior and posterior optic nerve head blood flow in nonhuman primate experimental glaucoma model measured by laser speckle imaging technique and microsphere method Invest Ophthalmol Vis Sci. 53 8303-1453
  • [9] Chiba N(2016)Optic nerve head blood flow, as measured by laser speckle flowgraphy, is significantly reduced in preperimetric glaucoma Curr Eye Res. 41 1447-7706
  • [10] Omodaka K(2013)Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma Invest Ophthalmol Vis Sci. 54 7699-1728
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