Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo–YAP1 pathway

被引:0
作者
Duanrui Liu
Yunyun Liu
Wenshuai Zhu
Yi Lu
Jingyu Zhu
Xiaoli Ma
Yuanxin Xing
Mingjie Yuan
Bin Ning
Yunshan Wang
Yanfei Jia
机构
[1] Shandong Provincial Hospital Affiliated to Shandong First Medical University,Department of Clinical Laboratory
[2] Jinan Central Hospital,Research Center of Basic Medicine
[3] Shandong University,Research Center of Basic Medicine
[4] Jinan Central Hospital,Department of Gastroenterology
[5] Shandong First Medical University,undefined
[6] Jinan Central Hospital,undefined
[7] Shandong First Medical University,undefined
[8] Central Hospital Affiliated to Shandong First Medical University,undefined
[9] Shandong First Medical University,undefined
来源
BMC Medicine | / 21卷
关键词
Gastric cancer; TET1; DNA demethylation; Hippo–YAP1 pathway;
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[1]  
Sung H(2021)Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin. 71 209-49
[2]  
Ferlay J(2017)How to stomach an epigenetic insult: the gastric cancer epigenome Nat Rev Gastroenterol Hepatol. 14 467-78
[3]  
Siegel RL(2010)Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells Cancer Res. 70 1430-40
[4]  
Laversanne M(2020)Discovery and validation of methylated-differentially expressed genes in Helicobacter pylori-induced gastric cancer Cancer Gene Ther. 27 473-85
[5]  
Soerjomataram I(2000)Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes DNA Res. 7 111-20
[6]  
Jemal A(2009)Association of GNB4 intron-1 haplotypes with survival in patients with UICC stage III and IV colorectal carcinoma Anticancer Res. 29 1271-4
[7]  
Padmanabhan N(2008)Characterization of intron-1 haplotypes of the G protein beta 4 subunit gene–association with survival and progression in patients with urothelial bladder carcinoma Pharmacogenet Genomics. 18 999-1008
[8]  
Ushijima T(2020)Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2 Acta Biochim Biophys Sin (Shanghai). 52 975-87
[9]  
Tan P(2018)A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells BMC Cancer. 18 817-54
[10]  
Niwa T(2015)5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer Biochim Biophys Acta. 1855 144-52