Evaluation of coagulation tests in mouse plasma

被引：0
|
作者：
M. Palm
L. Frankenberg
M. Johansson
E. Jalkesten
机构：
[1] Safety Assessment,
[2] Astra AB,undefined
来源：
Comparative Haematology International | 1997年 / 7卷
关键词：
APTT; Coagulation; Mouse; PT; TT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The coagulation variables thrombin time (TT), activated partial thrombin time (APTT) and prothrombin time (PT), were investigated in mouse plasma. TT and APTT clotting times were determined using a KC10 coagulation analyser and test kits Dia Thrombin (bovine thrombin diluted to a concentration of 2.5 U/l) and Dia Celin-L (rabbit brain cephaloplastin, activated with complexed Kaolin), respectively. PT was determined with IL Test™ Hepatocomplex (rabbit brain thromboplastin and calcium ions) using an ACL 200. Furthermore, the test procedures were also used to assess the anticoagulant status of mice treated orally with Melagatran, a thrombin inhibitor. The results showed that the kits could be used successfully on mouse plasma to measure the effect of a thrombin inhibitor on haemostasis.
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页码：243 / 246
页数：3
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