Spaceflight-Associated Neuro-Ocular Syndrome: Clinical Features and Classification

被引：0

作者：

Makarov I.A. ^{[1
]}

Voronkov Y.I. ^{[1
]}

Bogomolov V.V. ^{[1
]}

Alferova I.V. ^{[1
]}

机构：

[1] Institute of Biomedical Problems, Russian Academy of Sciences, Moscow

来源：

Human Physiology | 2021年 / 47卷 / 6期

关键词：

analysis of OCT images; papilledema; space flight;

D O I：

10.1134/S0362119721040101

中图分类号：

学科分类号：

摘要：

Abstract: Visual and quantitative analyses of fundus and optical coherent tomography (OCT) images of the optic nerve (ON) and retina were performed in Russian cosmonauts during a space flight (SF). The OCT images were used to measure the peripapillar retinal thickness, the ON head thickness, the distance between Bruch’s membrane, and the degree of excavation. A visual analysis of the fundus images did not always make it possible to accurately detect optic disc edema and to classify the changes with a papilledema scale. The quantitative analysis of the OCT images showed that assessing the peripapillar retinal and ON head thicknesses at several time points is more important in the diagnosis of papilledema than measuring the distance between Bruch’s membrane or the diameter and depth of the optic nerve head cup, especially at stages 0–II. The retinal thickness on opposite sides of the ON disc in in-flight OCT images was increased as compared with preflight images in all cases, suggesting ON head edema. A quantitative analysis of OCT images allows not only objective accurate diagnosis of papilledema, but also its classification by stage. An additional subclinical stage, where papilledema is diagnosed only by quantitative analysis of OCT images, was proposed to introduce in the classification. © 2021, Pleiades Publishing, Inc.

引用

页码：612 / 618

页数：6

共 17 条

[1]

Makarov I.A., Voronkov Y.I., Aslanjan M.G., Ophthalmic changes associated with long-term exposure to microgravity, Hum. Physiol, 43, (2017)

[2]

Johnston S.L., Arenare B.A., Smart K.T., Principles of Clinical Medicine for Space Flight, (2008)

[3]

Nelson E.S., Mulugeta L., Myers J.S., Microgravity-induced fluid shift and ophthalmic changes, Life, 4, (2014)

[4]

Mader T.H., Gibson C.R., Pass A.F., Optic disc edema in an astronaut after repeat long-duration space flight, J. Neuroophthalmol, 33, (2013)

[5]

Lee A.G., Mader T.H., Gibson C.R., Tarver W., Space flight-associated neuro-ocular syndrome, J.A.M.A. Ophthalmol, 135, (2017)

[6]

Tron E.Z., Zabolevaniya zritel’nogo Puti (Diseases of the Visual Tract), (1955)

[7]

Frisen L., Swelling of the optic nerve head: a staging scheme, J. Neurol. Neurosurg. Psychol, 45, (1982)

[8]

Hatem C.F., Yri H.M., Sorensen A.L., Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension, Acta Ophthalmol, 96, (2018)

[9]

Farmen A.H., Ringstad G., Kerty E., Idiopathic intracranial hypertension as a cause of headache, Tidsskr. Nor. Laegeforen, 136, (2016)

[10]

Zhou D., Meng R., Zhang X., Intracranial hypertension induced by internal jugular vein stenosis can be resolved by stenting, Eur. J. Neurol, 25, (2018)

← 1 2 →