X chromosome painting in Microtus: Origin and evolution of the giant sex chromosomes

被引：0
作者：
J. A. Marchal
M. J. Acosta
H. Nietzel
K. Sperling
M. Bullejos
R. Díaz de la Guardia
A. Sánchez
机构：
[1] Facultad de Ciencias Experimentales y de la Salud,Departamento de Biología Experimental
[2] Universidad de Jaén,undefined
[3] Institute of Human Genetics,undefined
[4] Charité,undefined
[5] Campus Virchow-Klinikum,undefined
来源：
Chromosome Research | 2004年 / 12卷
关键词：
chromosome painting; evolution; heterochromatin; X chromosome;
D O I：
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中图分类号：
学科分类号：
摘要：
Sex chromosomes in species of the genus Microtus present some characteristic features that make them a very interesting group to study sex chromosome composition and evolution. M. cabrerae and M. agrestis have enlarged sex chromosomes (known as ‘giant sex chromosomes’) due to the presence of large heterochromatic blocks. By chromosome microdissection, we have generated probes from the X chromosome of both species and hybridized on chromosomes from six Microtus and one Arvicola species. Our results demonstrated that euchromatic regions of X chromosomes in Microtus are highly conserved, as occurs in other mammalian groups. The sex chromosomes heterochromatic blocks are probably originated by fast amplification of different sequences, each with an independent origin and evolution in each species. For this reason, the sex heterochromatin in Microtus species is highly heterogeneous within species (with different composition for the Y and X heterochromatic regions in M. cabrerae) and between species (as the composition of M. agrestis and M. cabrerae sex heterochromatin is different). In addition, the X chromosome painting results on autosomes of several species suggest that, during karyotypic evolution of the genus Microtus, some rearrangements have probably occurred between sex chromosomes and autosomes.
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页码：767 / 776
页数：9
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