The host-tumor interface in B-cell non-Hodgkin lymphoma: A new world to investigate

被引：5
作者：
Rachinel N. [1 ]
Salles G. [1 ]
机构：
[1] Faculté de Médecine Lyon-Sud Charles Mérieux, 69495 Pierre-Bénite Cedex
来源：
Current Hematologic Malignancy Reports | 2009年 / 4卷 / 4期
关键词：
Lymphoma; Lymphoma Cell; Follicular Lymphoma; Mantle Cell Lymphoma; Lymphoid Organ;
D O I：
10.1007/s11899-009-0026-1
中图分类号：
学科分类号：
摘要：
Research on B-cell non-Hodgkin lymphoma focuses mainly on oncogenic events occurring in lymphoma cells, but recently a new component has appeared that may be crucial in lymphomagenesis: the tumor microenvironment. Indeed, compelling evidence demonstrates the key role played by nonmalignant bystander cells in the establishment and proliferation of the tumor. Among these cells, stromal cells, monocytes/ macrophages, and T cells in lymphoid organs have all been described as contributing to tumor progression. Interactions linked to cell-cell intimate contacts - but also mediated through soluble mediators such as cytokines and chemokines - do form a specific network. All these interrelations directed by the tumor create a friendly environment for lymphoma cells that permits them to proliferate. Blocking the cross-talk between the tumor microenvironment and lymphoma cells may thus represent a promising new strategy for treating B-cell malignancies. © Current Medicine Group, LLC 2009.
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页码：196 / 201
页数：5
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