Serum GGT activity and hsCRP level in patients with type 2 diabetes mellitus with good and poor glycemic control: An evidence linking oxidative stress, inflammation and glycemic control

被引：36

作者：

Gohel M.G. ^{[1
]}

Chacko A.N. ^{[2
]}

机构：

[1] Department of Biochemistry, B. J. Medical College and Civil Hospital, Ahmedabad

[2] Department of Biochemistry, GDERS Dental College, Siddhapur

来源：

Journal of Diabetes & Metabolic Disorders | / 12卷 / 1期

关键词：

Glycemic Control; Diabetes Mellitus Patient; Poor Glycemic Control; hsCRP Level; Good Glycemic Control;

D O I：

10.1186/2251-6581-12-56

中图分类号：

学科分类号：

摘要：

Background: Diabetes is undoubtedly one of the most challenging health problems in 21st century. Understanding the pathogenesis and preventing long term complications have been major goals of research in diabetes mellitus (DM). Research in the past few years has linked oxidative stress and inflammation to beta cell dysfunction. Aim of this study is to evaluate serum gamma-glutamyl transferase (GGT) activity (marker of oxidative stress) and high sensitivity C reactive protein (hsCRP) level (an inflammatory marker) in type 2 DM subjects with good and poor glycemic control. Further, we investigated correlation between serum GGT and hsCRP level with glycemic control (FBS, PP2BS, HbA1c) in subjects.Methods: A cross sectional study consists of 150 patients out of them 50 patients having type 2 DM with good control (Group II), 50 patients with type 2 DM with poor control (Group III) and 50 normal healthy control (Group I) were selected. Serum GGT, serum hsCRP, FBS, PP2BS, HbA1c, and other biochemical investigations include serum liver enzymes and lipids were measured.Results: Mean serum GGT and hsCRP concentration were statistically significantly higher in group III patients compared to group I and group II subjects as well as increased in group II compared to group I (p < 0.001). Further significant positive correlation was observed between GGT and hsCRP concentration as well as both with HbA1c, FBS, and PP2BS.Conclusions: Oxidative stress and inflammation appears to be a key component and also associated with poor glycemic control and further pathogenesis of diabetes and its complications. All our finding suggesting a link between oxidative stress, inflammation and glycemic control in patient with type 2 diabetes mellitus. © 2013 Gohel and Chacko; licensee BioMed Central Ltd.

引用

共 39 条

[1]

Alvin C., Powers: diabetes mellitus, Harrison's Principle of Internal Medicine, pp. 2152-2179, (2005)

[2]

Thakur S., Chauhan V., Negi R.C., Role of HbA1C in diabetes mellitus, J Indian Acad Clin Med, 10, 1-2, pp. 52-54, (2009)

[3]

Ford E.S., The metabolic syndrome and C-reactive protein, fibrinogen and leucocyte count: findings from the third national health and nutrition examination survey, Atherosclerosis, 168, pp. 351-358, (2003)

[4]

Emdin M., Pompella A., Paolicchi A., Gammaglutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque, Circulation, 112, pp. 2078-2080, (2005)

[5]

Karp D.R., Shimooku K., Lipsky P.E., Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death, J Biol Chem, 276, pp. 3798-3804, (2001)

[6]

Droge W., Free radicals in the physiological control of cell function, Physiol Rev, 82, pp. 47-95, (2002)

[7]

Rosen P., Nawroth P.P., King G., Moller W., Tritschler H.J., Packer L., The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a congress series sponsored by UNESCO-MCBN, the American diabetes association and the German diabetes society, Diabetes Metabolic Research Rev, 17, pp. 189-212, (2001)

[8]

Marchesini G., Brizi M., Bianchi G., Nonalcoholic fatty liver disease: a feature of the metabolic syndrome, Diabetes, 50, pp. 1844-1850, (2001)

[9]

Lee D.H., Ha M.H., Kim J.H., Gamma-glutamyltransferase and diabetes: a 4 year follow-up study, Diabetologia, 46, pp. 359-364, (2003)

[10]

Pfutzner A., Forst T., High-sensitivity C-reactive protein as cardio-vascular risk marker in patients with diabetes mellitus, Diabetes Technol Ther, 8, 1, pp. 28-36, (2006)

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