18F-labeling techniques for positron emission tomography

被引：0
作者：
Ying Li
机构：
[1] Nanjing University of Information Science & Technology,Jiangsu Key Laboratory of Atmospheric Environment Monitoring & Pollution Control, Chemistry Department, School of Environmental Science & Engineering
来源：
Science China Chemistry | 2013年 / 56卷
关键词：
molecular imaging; positron emission tomography; F-fluorine/fluoride; specific activity; radiochemical yield;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Much research effort has been made to understand various biological processes at levels of molecules using molecular imaging techniques. Because of great sensitivity, high resolution, and rapid detection, positron emission tomography (PET) imaging is becoming one of the most used imaging techniques for medical diagnose and pre-clinical studies. Here we provide a review on molecular imaging and PET imaging. An introduction is also provided on 18F-fluorine labeling techniques for the preparation of PET imaging probes. A summary and comparison of currently available 18F-fluorine labeling methods is provided. The perspectives for 18F-fluorine labeling techniques are also given.
引用
收藏
页码：1682 / 1692
页数：10
相关论文
共 643 条
  • [61] Yang W(2008)A rapid synthesis of 2-deoxy-2-fluorodeuterium-glucose from xenon difluoride suitable for labeling with F-18 Radiochim Acta 96 845-848
  • [62] Lin Y(1986)Radiofluorination with xenon difluoride — A new high-yield synthesis of [F-18]2-fluoro-2-deoxydeuterium-glucose J Nucl Med 27 235-238
  • [63] Zhang X(2008)Radiofluorination with xenon difluoride- Nuklearmed Nucl Med 47 116-119
  • [64] Zhang J(2007)-6[F-18]fluoro-dopa Mini-Rev Org Chem 4 317-329
  • [65] Wang X(2009)Aromatic fluorination with xenon difluoride — Sci China Chem 52 2195-2199
  • [66] Zhu Z(2003)-3,4-Dihydroxy-6-fluoro-phenylalanine J Labelled Compd Radiopharm 46 805-814
  • [67] Zhao X(2008)Investigations to the synthesis of n.c.a. F-18 FClO J Med Chem 51 3700-3712
  • [68] Qin W(2009) as electrophilic fluorinating agent J Med Chem 52 5816-5825
  • [69] Chen G(2010)A new improved synthesis of 2-deoxy-2-(F-18)fluoro-D-glucose from F-18-labeled acetyl hypofluorite Bioconjugate Chem 21 2282-2288
  • [70] Qian J(2006)Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D-glucose — Concise communication Bioorg Med Chem Lett 16 5767-5772
234567891011