The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

被引：0
作者：
R Wäsch
J A Robbins
F R Cross
机构：
[1] University Medical Center,Department of Hematology and Oncology
[2] Laboratory of Yeast Molecular Genetics,undefined
[3] The Rockefeller University,undefined
[4] New York,undefined
[5] NY,undefined
[6] USA,undefined
来源：
Oncogene | 2010年 / 29卷
关键词：
anaphase-promoting complex; ubiquitin; proteasome; differentiation; genomic instability; tumor suppression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation. Misregulation of Cdh1 thus has the potential to promote both cell-cycle re-entry and either perturbed differentiation or dedifferentiation. In addition, APC/CCdh1 is required to maintain genomic stability. As a result, loss of Cdh1 can contribute to tumorigenesis in the form of proliferation of poorly differentiated and genetically unstable cells.
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页码：1 / 10
页数：9
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