Impact of Omission or Replacement of Data Below the Limit of Quantification on Parameter Estimates in a Two-Compartment Model

被引：0

作者：

Vincent Duval

Mats O. Karlsson

机构：

[1] IRIS,Department of Clinical Pharmacokinetics

[2] Uppsala University,Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Faculty of Pharmacy

来源：

Pharmaceutical Research | 2002年 / 19卷

关键词：

NONMEM; pharmacokinetics; limit of quantification; parameter estimates; bias;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. To evaluate the influence of omission and replacement approaches for data below the limit of quantification (LOQ) on the estimation of pharmacokinetic parameters for two-compartment models when using nonlinear mixed-effect models.

引用

页码：1835 / 1840

页数：5

共 44 条

[41] EVALUATION OF THE IMPACT OF OMITTING DRUG CONCENTRATION DATA BELOW THE LOWER LIMIT OF QUANTIFICATION (LLOQ) ON THE PHARMACOKINETICS (PK) OF AXITINIB (AG-013736), AN ANTI-ANGIOGENIC AGENT.
Garrett, M.
Amantea, M. A.
Pithavala, Y. K.
Ruiz-Garcia, A.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 : S78 - S79
[42] Errata: Ways to Fit a PK Model with Some Data Below the Quantification Limit, Stuart L. Beal, J. Pharmacokin. Pharmacodyn.28:481–504 (2001)
Journal of Pharmacokinetics and Pharmacodynamics, 2002, 29 (3) : 309 - 309
[43] Kinetic modeling using a two-tissue compartment model and an additional irreversible vascular component improves the quantification of [11C]PBR28 brain PET data
Rizzo, Gaia
Veronese, Mattia
Tonietto, Matteo
Zanotti-Fregonara, Paolo
Turkheimer, Federico
Bertoldo, Alessandra
JOURNAL OF NUCLEAR MEDICINE, 2014, 55
[44] Kinetic modeling using a two-tissue compartment model and an additional irreversible vascular component improves the quantification of [11C]PBR28 brain PET data
Rizzo, Gaia
Veronese, Mattia
Tonietto, Matteo
Zanotti-Fregonara, Paolo
Turkheimer, Federico
Bertoldo, Alessandra
JOURNAL OF NUCLEAR MEDICINE, 2014, 55

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