Memory T Cells in Transplantation

被引：3
作者：
Su C.A. [1 ,2 ]
Fairchild R.L. [1 ,2 ]
机构：
[1] Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH
[2] Glickman Urological and Kidney Institute and Department of Immunology, Cleveland Clinic Foundation, Cleveland, 44195, OH
来源：
Current Transplantation Reports | 2014年 / 1卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Animal models; Heterologous immunity; Homeostatic proliferation; Memory T cells; Transplant tolerance; Transplantation;
D O I：
10.1007/s40472-014-0018-5
中图分类号：
学科分类号：
摘要：
Following infections and other environmental exposures, the resulting primary immune response generates memory T cells that provide long-term protective immunity. Compared to their naïve T cell counterparts, memory T cells possess unique characteristics that endow them with the ability to quickly and robustly respond to foreign antigens. While such memory T cells are beneficial in protecting hosts from recurrent infection, memory cells reactive to donor antigens pose a major barrier to successful transplantation and tolerance induction. Significant progress has been made over the past decade contributing to our understanding of memory T cell generation, their distinct biology, and their detrimental impact in clinical and animal models of transplantation. This review focuses on the unique features that make memory T cells relevant to the transplant community and discusses potential therapies targeting memory T cells which may ameliorate allograft rejection and improve graft outcomes. © 2014, Springer International Publishing AG.
引用
收藏
页码：137 / 146
页数：9
相关论文
共 84 条
[1]  
Kaech S.M., Cui W., Transcriptional control of effector and memory CD8+ T cell differentiation, Nat Rev Immunol, 12, pp. 749-761, (2012)
[2]  
Kaech S.M., Wherry E.J., Ahmed R., Effector and memory T-cell differentiation: implications for vaccine development, Nat Rev Immunol, 2, pp. 251-262, (2002)
[3]  
Moulton V.R., Farber D.L., Committed to memory: lineage choices for activated T cells, Trends Immunol, 27, pp. 261-267, (2006)
[4]  
Joshi N.S., Cui W., Chandele A., Lee H.K., Urso D.R., Hagman J., Et al., Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor, Immunity, 27, pp. 281-295, (2007)
[5]  
Sprent J., Tough D.F., Lymphocyte life-span and memory, Science, 265, pp. 1395-1400, (1994)
[6]  
Jamieson B.D., Douek D.C., Killian S., Hultin L.E., Scripture-Adams D.D., Giorgi J.V., Et al., Generation of functional thymocytes in the human adult, Immunity, 10, pp. 569-575, (1999)
[7]  
Tchao N.K., Turka L.A., Lymphodepletion and homeostatic proliferation: implications for transplantation, Am J Transplant, 12, pp. 1079-1090, (2012)
[8]  
Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D., Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells, J Exp Med, 195, pp. 1523-1532, (2002)
[9]  
Goldrath A.W., Bogatzki L.Y., Bevan M.J., Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation, J Exp Med, 192, pp. 557-564, (2000)
[10]  
Moxham V.F., Karegli J., Phillips R.E., Brown K.L., Tapmeier T.T., Hangartner R., Et al., Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection, J Immunol, 180, pp. 3910-3918, (2008)
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