Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

[1] Hooten KG(2015)Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis Neurotherapeutics 12 364-375

[2] Beers DR(2008)CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS Proc Natl Acad Sci U S A 105 15558-15563

[3] Zhao W(2015)Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice Ann Neurol 77 75-99

[4] Appel SH(2012)Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS J Clin Invest 122 3063-3087

[5] Beers DR(2013)Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival EMBO Mol Med 5 64-79

[6] Henkel JS(2012)Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms Neurobiol Dis 48 418-428

[7] Zhao W(2016)Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions Semin Immunol 28 292-308

[8] Wang J(2013)Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis J Neuroinflammation 10 119-E4392

[9] Appel SH(2013)C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice Proc Natl Acad Sci U S A 110 E4385-20965

[10] Butovsky O(2009)Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice Proc Natl Acad Sci U S A 106 20960-8734

[1] Hooten KG(2015)Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis Neurotherapeutics 12 364-375

[2] Beers DR(2008)CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS Proc Natl Acad Sci U S A 105 15558-15563

[3] Zhao W(2015)Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice Ann Neurol 77 75-99

[4] Appel SH(2012)Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS J Clin Invest 122 3063-3087

[5] Beers DR(2013)Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival EMBO Mol Med 5 64-79

[6] Henkel JS(2012)Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms Neurobiol Dis 48 418-428

[7] Zhao W(2016)Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions Semin Immunol 28 292-308

[8] Wang J(2013)Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis J Neuroinflammation 10 119-E4392

[9] Appel SH(2013)C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice Proc Natl Acad Sci U S A 110 E4385-20965

[10] Butovsky O(2009)Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice Proc Natl Acad Sci U S A 106 20960-8734