FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China

被引：7
作者：
Meilin Wang
Dongmei Wu
Ming Tan
Weida Gong
Hengchuan Xue
Hongbin Shen
Zhengdong Zhang
机构：
[1] Nanjing Medical University,Department of Molecular and Genetic Toxicology, Cancer Center
[2] Yangzhong Cancer Research Institute,Department of Epidemiology and Statistics, Cancer Center
[3] Yixing People’s Hospital,undefined
[4] Nanjing Medical University,undefined
来源：
Biochemical Genetics | 2009年 / 47卷
关键词：
ligand; Gastric cancer; Susceptibility; Molecular epidemiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes can alter transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS −1377G>A, FAS −670A>G, and FASLG −844T>C polymorphisms in the promoter regions are associated with risk of gastric cancer. In a population-based case-control study of 332 gastric cancer cases and 324 controls, we genotyped these three polymorphisms and evaluated their association with risk of gastric cancer. We found that the FAS and FASL genotypes and the FAS haplotypes had no significant associations with risk of gastric cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of gastric cancer. The FAS and FASLG polymorphisms may not contribute to risk of gastric cancer in the southern Chinese population.
引用
收藏
页码：559 / 568
页数：9
相关论文
共 229 条
[1]  
Chen JY(2005)The −844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE Genes Immun 6 123-128
[2]  
Wang CM(2004)Epidemiology of upper gastrointestinal malignancies Semin Oncol 31 450-464
[3]  
Ma CC(2001)Proliferation, cell cycle and apoptosis in cancer Nature 411 342-348
[4]  
Chow YH(1997)Identification and characterization of polymorphisms in the promoter region of the human Apo-1/Fas (CD95) gene Mol Immunol 34 577-582
[5]  
Luo SF(2002)A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus J Rheumatol 29 1183-1188
[6]  
Crew KD(2004)Re: polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma J Natl Cancer Inst 96 1478-1479
[7]  
Neugut AI(2003)Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis Int J Cancer 103 221-225
[8]  
Evan GI(1999)Transitional cell carcinoma expresses high levels of Fas ligand in vivo BJU Int 83 698-702
[9]  
Vousden KH(1999)Alterations of Fas (APO-1/CD95) gene in transitional cell carcinomas of urinary bladder Cancer Res 59 3068-3072
[10]  
Huang QR(2005)Exon 3 polymorphisms and haplotypes of Cancer Lett 227 49-57
12345678910