Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer

被引：0
|
作者：
Huan Yang
Xing Xiao
Leli Zeng
Haiteng Zeng
Yueyuan Zheng
Jingshu Wang
Guanghua Li
Weigang Dai
Yulong He
Suihai Wang
Jianjun Peng
Wei Chen
机构：
[1] The First Affiliated Hospital of Sun Yat-Sen University,Department of Gastrointestinal Surgery
[2] Guangdong Provincial Key Laboratory of Digestive Cancer Research,Department of Biobank
[3] The Seventh Affiliated Hospital of Sun Yat-Sen University,Clinical Big Data Research Center, Scientific Research Center
[4] The Seventh Affiliated Hospital of Sun Yat-Sen University,Department of Oncology, Sun Yat
[5] Sun Yat-Sen University,Sen Memorial Hospital
[6] The Seventh Affiliated Hospital of Sun Yat-Sen University,Department of Gastrointestinal Surgery
[7] Southern Medical University,School of Laboratory Medicine and Biotechnology
来源：
Journal of Translational Medicine | / 22卷
关键词：
Liquid biopsy; cfDNA; Colorectal cancer; Organoid; PIK3CA; Alpelisib;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 10 条
  • [1] Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer
    Yang, Huan
    Xiao, Xing
    Zeng, Leli
    Zeng, Haiteng
    Zheng, Yueyuan
    Wang, Jingshu
    Li, Guanghua
    Dai, Weigang
    He, Yulong
    Wang, Suihai
    Peng, Jianjun
    Chen, Wei
    JOURNAL OF TRANSLATIONAL MEDICINE, 2024, 22 (01)
  • [2] PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment
    Leiphrakpam, Premila D.
    Are, Chandrakanth
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (06)
  • [3] To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway
    Zhong, Jiateng
    Ding, Shuang
    Zhang, Xinyu
    Di, Wenyu
    Wang, Xiaohui
    Zhang, Hui
    Chen, Yiyang
    Zhang, Yongxi
    Hu, Yuhan
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, 28 (02): : 37
  • [4] A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid
    Park, Se-Ra
    Kim, Soo-Rim
    Hong, In-Sun
    Lee, Hwa-Yong
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [5] The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review
    Demir, Kubra
    Turgut, Rana
    Senturk, Selcen
    Isiklar, Handan
    Gunalan, Elif
    FOOD SCIENCE & NUTRITION, 2024, : 9951 - 9973
  • [6] Discovery of a selective PI3Kα inhibitor via structure-based virtual screening for targeted colorectal cancer therapy
    Albassam, Hussam
    Almutairi, Omar
    Alnasser, Majed
    Altowairqi, Faisal
    Almutairi, Faris
    Alobid, Saad
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2025, 40 (01)
  • [7] EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway
    Zhang Juan
    Chu Dake
    Tanaka, Kiyohito
    He Shuixiang
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2021, 26 (06) : 1099 - 1108
  • [8] EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway
    Zhang Juan
    Chu Dake
    Kiyohito Tanaka
    He Shuixiang
    International Journal of Clinical Oncology, 2021, 26 : 1099 - 1108
  • [9] Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells
    Wang, Qun
    Lu, Weijun
    Yin, Tao
    Lu, Li
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (1)
  • [10] Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells
    Qun Wang
    Weijun Lu
    Tao Yin
    Li Lu
    Journal of Experimental & Clinical Cancer Research, 38
1