Clinical Potential of Growth Hormone in the Treatment of Congestive Heart Failure

被引：0
|
作者：
Jörgen Isgaard
Claes-Håkan Bergh
机构：
[1] Sahlgrenska University Hospital,Research Center for Endocrinology and Metabolism
[2] Sahlgrenska University Hospital,Division of Cardiology
来源：
BioDrugs | 1999年 / 12卷
关键词：
Growth Hormone; Adis International Limited; Dilate Cardiomyopathy; Growth Hormone Receptor; Idiopathic Dilate Cardiomyopathy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Substantial evidence supports a role for the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis in regulation of normal cardiac growth, structure and function. Moreover, experimental data suggest beneficial effects of GH and IGF-1 on contractility and peripheral resistance in rats with impaired cardiac function. An increased Ca++ responsiveness is one possible underlying cause for the improvement in contractility, although effects of GH and IGF-1 on apoptosis may also play a more long term role for cardiomyocyte survival.
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页码：245 / 250
页数：5
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