Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function

被引：0
作者：
Hisashi Hashimoto
Atsumi Kojima
Tamotsu Sudo
Noriyoshi Ohki
Satoshi Yamaguchi
Yoshiki Mikami
Masaharu Ito
Ryuichiro Nishimura
机构：
[1] Hyogo Cancer Center,Department of Translational Research
[2] Hyogo Cancer Center,Department of Gynecologic Oncology
[3] Kyoto University Hospital,Department of Diagnostic Pathology
[4] Ehime University School of Medicine,Department of Obstetrics and Gynecology
来源：
Human Cell | 2008年 / 21卷
关键词：
cell line; human; p53; papillary carcinoma; uterine neoplasm;
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学科分类号：
摘要：
Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.
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页码：64 / 69
页数：5
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