Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC–MS with solid-phase extraction

被引：1
作者：
Koichi Suenami
Lee Wah Lim
Toyohide Takeuchi
Yasuhide Sasajima
Kiyohito Sato
Yuji Takekoshi
Susumu Kanno
机构：
[1] Gifu University,Department of Chemistry, Faculty of Engineering
[2] Gifu Pref. Police H.Q.,Criminal Investigation Laboratory
来源：
Analytical and Bioanalytical Chemistry | 2006年 / 384卷
关键词：
Nonsteroidal anti-inflammatory drugs; Liquid chromatography–mass spectrometry; Solid-phase extraction; Human plasma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A rapid, selective and sensitive analytical method for the simultaneous determination of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma was carried out using Oasis HLB solid-phase extraction (SPE), followed by reversed-phase high-performance liquid chromatography and quadrupole mass spectrometry with electrospray ionization operated in the negative ion mode. The recoveries of NSAIDs from human plasma by SPE were greater than 76.7%. The use of a short column packed with small particles enabled rapid and simultaneous determination within 7 min. The detection limits for the NSAIDs were 0.01–0.9 μg/ml using the selected ion monitoring mode.
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页码：1501 / 1505
页数：4
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