Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N4 Schiff Base Complexes

被引：0
|
作者：
A. M. Naglah
M. A. Al-Omar
A. Kalmouch
A. A. Gobouri
S. H. Abdel-Hafez
S. M. El-Megharbel
M. S. Refat
机构：
[1] King Saud University,Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy
[2] National Research Centre,Peptide Chemistry Department, Chemical Industries Research Division
[3] Taif University,Chemistry Department, Faculty of Science
[4] Assiut University,Chemistry Department, Faculty of Science
[5] Zagazig University,Chemistry Department, Faculty of Science
[6] Port Said University,Department of Chemistry, Faculty of Science
来源：
Russian Journal of General Chemistry | 2019年 / 89卷
关键词：
Schiff base; aminoantipyrine; gold; complexes; TEM; nanoparticles; spectroscopy;
D O I：
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学科分类号：
摘要：
Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vis, 1H, and 13C NMR) data. Au(III) Ion is coordinated with the synthesized Schiff bases via four nitrogen atoms of the antipyrine and azomethine groups. Au(III) Complexes are electrolytes with three uncoordinated Cl− ions, and have a square planar geometry. Their morphology is characterized by SEM and TEM methods. Cytotoxic effect of the complexes is tested against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines.
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页码：1702 / 1706
页数：4
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